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HIV is devastating to the immune system because it destroys helper T cells,which are important for both humoral and cell-mediated immunity.If both humoral and cell-mediated immunity are nonfunctional,the body has no remaining defense against pathogens.

A) True
B) False

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What is part of the body's initial line of defense against pathogens?


A) Phagocytes
B) Mucous membranes
C) B cells
D) Memory T cells
E) Cytokines

F) B) and E)
G) A) and B)

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In mammalian defenses against invading pathogens,all of these are considered nonspecific defense mechanisms EXCEPT


A) acquired immunity.
B) the skin.
C) mucous membranes.
D) the inflammatory response.
E) antimicrobial proteins (E.g. ,interferon) .

F) A) and D)
G) B) and E)

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Specific immunity in the extracellular fluid is provide by mainly


A) IgG and IgM
B) IgM and IgD
C) IgA and IgE
D) IgD and IgA
E) IgE and IgG

F) None of the above
G) A) and D)

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A certain virus has evolved a novel virus coat protein that has never existed before. Which of the following molecules will still be able to bind this novel antigen? (Check all that apply.)


A) immunoglobulin
B) perforin
C) T-cell receptor
D) Toll-like receptor

E) All of the above
F) B) and C)

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The three major types of pathogens are bacteria,viruses,and cancer.

A) True
B) False

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Immunoglobulins counteract microbes in all of the following ways EXCEPT which?


A) perforating the microbial cell membrane
B) binding toxins
C) linking microbes to complement proteins
D) linking microbes to phagocytes
E) linking microbes to NK cells

F) None of the above
G) A) and D)

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A doctor discovers that her patient can produce antibodies against some bacterial pathogens,but he is unable to protect himself against viral infections.The doctor suspects a disorder in her patient's


A) B cells.
B) plasma cells.
C) cytotoxic T cells.
D) suppressor T cells.
E) macrophages.

F) A) and B)
G) B) and C)

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Helper T cells activate both B cells and cytotoxic T cells.

A) True
B) False

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It is estimated that humans can produce over 1.5 million different types of antibodies.Which of the following statements regarding this extraordinary variation is INCORRECT?


A) We inherit over 1.5 million different and distinct immunoglobulin genes from our parents at fertilization.
B) V and J domains of antibody light chains are randomly joined.
C) Random segments of DNA can be removed from antibody genes.
D) V and J domains of antibody heavy chains are randomly joineD.
E) Cytosines in the variable regions of antibody genes can be converted to uracils via hypermutation.

F) A) and C)
G) B) and E)

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_________ is a characteristic of the early stages of a local inflammation response.


A) Arteriole constriction
B) Fever
C) Attack by cytotoxic T cells
D) Release of histamines
E) Release of CD4

F) A) and B)
G) C) and E)

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The 1918 influenza pandemic was notable for the number of people who died,particularly young people with healthy immune systems.Scientists believe that the deaths may have been caused by an overreaction of the immune system to infection.An out-of-control positive feedback loop can occur,because helper T cells and macrophages can both respond to and also secrete __________.


A) cytokines
B) immunoglobulins
C) perforin
D) proteases
E) T cell receptors

F) None of the above
G) A) and D)

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Which of the following is TRUE of both T cells and B cells?


A) They are lymphocytes.
B) They recognize specific antigens on the cell surface.
C) When activated,they proliferate to form both effector cells and memory cells.
D) They are involved in the humoral immune response.
E) All of the responses are correct.

F) C) and D)
G) B) and E)

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PAMP is an enzyme involved in creating immunoglobulin light chains.

A) True
B) False

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Antigen-presenting cells include


A) macrophages.
B) macrophages and B cells.
C) dendritic cells and macrophages.
D) dendritic cells and B cells.
E) macrophages,B cells and dendritic cells.

F) A) and E)
G) A) and D)

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Humoral immunity is mostly the function of


A) cytotoxic T cells.
B) B cells.
C) Class I MHC.
D) complement cells.
E) mast cells.

F) A) and B)
G) B) and E)

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Cytotoxic T cells destroy cancerous cells by


A) forming the membrane attack complex.
B) releasing vesicles containing proteases and perforin.
C) activating natural killer cells.
D) opsonization.
E) secreting cytokines.

F) B) and C)
G) A) and B)

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The first stage of a specific immune response is the proliferation of B cells and T cells.

A) True
B) False

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The clonal selection theory implies that


A) related people have similar immune responses.
B) antigens activate specific lymphocytes.
C) only certain cells can produce interferon.
D) memory cells are present at birth.
E) the body selects which antigens it will respond to.

F) B) and E)
G) B) and D)

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Which of the following is NOT a part of the lymphatic system?


A) Tonsils
B) Spleen
C) Lymph node
D) Bone marrow
E) Pancreas

F) D) and E)
G) C) and E)

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